Abstract: Background: Tele-nursing is a technology-based nursing service that was created to provide convenience health services for all patients with chronic diseases including hemodialysis patients. Purpose of the study was to examine the effect of tele-nursing education intervention on self-efficacy and quality of life of hemodialysis patients. Design: A quasi- experimental (study and control group) with pre and post research design was used. Setting: This study was conducted at kidney dialysis unit at AL Shuhada Central Hospital and kidney dialysis unit affiliated with the Association for the Preservation of the Holy Quran at Al Shuhada district, Menoufia Governorate, Egypt. Sample: A purposive sample of 100 hemodialysis patients who were assigned randomly into two equal groups (study group and control group 50 subjects for each one). Instruments:- A structured interviewing questionnaire including socio-demographic characteristics, medical history, clinical status as well as bio-physiological measurements, self- efficacy scale for hemodialysis patients and Kidney disease quality of life short-form questionnaire. Results: - There was a significant improvement in mean scores and levels of self-efficacy and quality of life at post-test1 and post-test 2 than pre-test of tele-nursing education intervention among the study group compared to the control group. Conclusion:- Tele-nursing education intervention was an effective method to improve hemodialysis patients' self-efficacy and quality of life among the study group compared to the control group. Recommendations: Tele-nursing educational intervention should be integrated in providing continuous care and follow-ups for hemodialysis patients.