Background: Higher education institutions are now using blended learning. Through the use of technology and
the internet, it combines in-person instruction with online learning to enhance student learning by making it more
student-centered model. Aim: To assess the challenges faced by undergraduate nursing students related to blended
learning during COVID-19 pandemic. Subjects and Method: Design: a descriptive design was utilized. Subjects: (344)
participants from undergraduate students in their first and second level who were enrolled in the study and applied
blended learning approach for one semester during the academic year 2021–2022. Tools: structured interview
questionnaire was used to gather data consists of two parts (assessment data sheet and questionnaire of blended learning
challenges).Results: (31.1%) of the first- level students and (57.6%) of the second level students use the mobile as device
for e-learning. (33.4%) of the first level students and (55.3%) of second level students had internet facility at home.
(25%) of the first level students and (41%) of the second level students did not have computing experience. Conclusion:
the most obstacles facing the students were infrastructure and technology, students 'characteristics dimension. There is
no significant difference noticed between challenges and both of gender, residence and marital status either first or
second level group. Recommendation: in the light of the current study, the institution must support students with
facilities such as internet access and trained instructors that help them to use e-learning applications easily and correctly.