Acne is an inflammatory disease of the sebaceous glands that results in the formation of papules, pustules, and more advanced complicated scars by opportunistic microorganisms known as Propionibacterium acnes, which feed mainly on fat. This resulted in the development of this acne condition. Reduced use of antibiotics and discovery of medicinal plant treatments because most bacteria become resistant over time. Propionibacterium acnes is a Gram-positive bacterium that plays a major role in the development of some diseases. This study investigated the effect of bread yeast extract against Propionibacterium acnes, which causes acne. The study involved 65 samples collected from 45 patients with acne, 40 of which were comedones and 25 of which were pustules. These samples were collected from adolescent patients at Kirkuk Hospitals (Azadi Teaching Hospital and Kirkuk General Hospital/dermatology outpatient clinics). The patients' ages ranged between (15-30 years old). All 65 purified samples showed P. acne. In this study, we investigated the effects of S. cerevisiae yeast on the growth of P. acne bacteria. A marked effect was observed through the inhibition of the growth of this bacteria, as the diameter of inhibition resulting from the effect of the extract of Saccharomyces cerevisiae ranged from 9.5 mm to 11.5 mm. Based on these results, Can be used the Saccharomyces cerevisiae for acne-related skin treatment.