This study investigates the potential of Moringa oleifera seed meal (MOSM) as a feed replacement of soya bean meal for poultry. The investigation was carried out at the Department of Animal and Poultry Production farm at Arish University, North Sinai, Egypt. A total of 120 one-day-old Ross chicks weighing between 40 and 50 g were selected for the study and were allowed to acclimate for seven days at the experimental site. The birds were incubated and fed on a baseline diet for a week to acclimate them before being randomly divided into four treatment groups, each with 30 birds and three replicates with 10 chicks each. Four levels of MOSM (0.0, 1, 2 and 3 % were substituted from soya bean) were fed during the experimental period for (7-35days). Body weight, weight gain, and feed intake were recorded. The feed conversion ratio (g, feed /g, gain) and protein conversion ratio (g, protein/g, gain) were calculated. At the end of the experiment carcass characteristics were measured, and blood samples were taken to determine some blood protein constituents. The economic efficiency values of dietary treatments were calculated. The results revealed that, birds fed diet containing 23 and 19% crude protein diet with MOSM during starter and grower period, respectively recorded significantly (P≤0.05) the best body weight, body gain, feed conversion ratio, protein utilization ratio and nutrients digestive compared with control diet. The chicks on the diet with 1% MOSM had the highest nitrogen balance.