The aim of the current study was to develop Egyptian first year EFL Faculty of Biotechnology students' higher order thinking skills (HOTS), vocabulary acquisition and speaking fluency through a proposed program integrating mobile-assisted language learning (MALL) and reciprocal listening to podcasts. The study followed the pretest/ posttest one experimental group design. The study group consisted of forty students; they were taught by the researcher throughout the fall semester of the academic year 2021- 2022 according to the proposed program. The study tools included a pre- /post- higher order thinking skills test, a pre-/post vocabulary acquisition test, a pre- post speaking fluency test, a rubric for measuring the study participants' HOTS and a speaking fluency rubric. Results indicated that there were statistically significant differences between the study group students' pre-tests and post-tests scores in favour of the post- tests scores. Therefore, it was concluded that the proposed program was effective in developing the study group students' HOTS, vocabulary and oral fluency.