One of the pseudo-cereal cereals that are high in both macronutrients and micronutrients is quinoa. This research records changes in the phenolic content and antioxidant bioactivity of quinoa seeds during germination. This study's objective was to assess the impacts of quinoa sprouts (QS) on dexamethasone- induced insulin resistance rats. Thirty-five Sprague-Dawley adult male rats were divided into five groups. Group (1) served as a negative control group and was given a basal diet, While the other rats (n= 28) were injected intraperitoneally with dexamethasone (Dexa) in a dose of (1 mg/kg b.wt) 3 times/ week for 6 weeks to induce insulin resistance. Group (2) was then maintained as insulin resistance rats (positive control) and the other three groups were given 10, 15, and 20% of QS, respectively. The findings revealed that the germination of quinoa improved the phenolic content and antioxidant activity of quinoa seeds and decreased anti-nutritional factors. Meanwhile, administration of QS significantly reversed the biochemical parameters induced by Dexa in rats, it caused significant changes in body weight gains, feed efficiency ratio, feed intake, and decreased serum liver, kidney function, and lipid profile. It also decreased fasting insulin, fasting glucose, glucose tolerance, and HOMA-IR. Furthermore, significantly increased in antioxidant enzymes (SOD, CAT, Gpx and TAC) while a decrease in MDA, serum cytokines as interleukin-1 (IL-β1) and tumor necrotic factor-α (TNF-α) in insulin resistance rats. In conclusion, incorporating quinoa sprouts as functional food ingredients should be taken into consideration given their positive effects and possible health benefits in reducing inflammation and oxidative stress in insulin resistance rats