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299646

Unveiling the Hepatoprotective and Ameliorative Potential of Natural Products in Paracetamol Overdose

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Last updated: 04 Jan 2025

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Abstract

Paracetamol (Acetaminophen; N-acetyl-P- aminophenol) is a broadly used analgesic and antipyretic prescription that can have fatal side effects when used in high dosages. Conventional treatment options for paracetamol overdose are limited and often ineffective, highlighting the need for alternative therapies. In recent years, there has been a growing interest in exploring natural remedies as potential alleviating interventions for paracetamol overdose. This comprehensive review explores the evidence-based natural therapies that have been studied for their effectiveness in reducing paracetamol toxicity. The review examines the mechanisms of action and safety profiles of these natural therapies, as well as their potential limitations and future research directions. The natural remedies discussed in this review include N-acetylcysteine, palm date, milk thistle, curcumin, ginger, and several others. Overall, this review highlights the potential of certain traditional hepatoprotective plants as effective and safe protective options against paracetamol overdose and emphasizes the need for further research to establish their clinical efficacy and safety.

DOI

10.21608/jmals.2023.299646

Keywords

Paracetamol, toxicity, N-acetyl cysteine, Natural therapy

Authors

First Name

1. Nada

Last Name

Badr

MiddleName

S.

Affiliation

Zoology Department, Faculty of Science, Damanhur University, Egypt

Email

nada.shaaban@sci.dmu.edu.eg

City

-

Orcid

-

First Name

Hagar

Last Name

Elbalakousy

MiddleName

H.

Affiliation

Zoology Department, Faculty of Science, Damanhur University, Egypt

Email

-

City

-

Orcid

-

First Name

Heba

Last Name

Mohamed

MiddleName

F.

Affiliation

Zoology Department, Faculty of Science, Damanhur University, Egypt

Email

-

City

-

Orcid

-

First Name

Hend

Last Name

Elgendy

MiddleName

A.

Affiliation

Zoology Department, Faculty of Science, Damanhur University, Egypt

Email

-

City

-

Orcid

-

First Name

Mohamed

Last Name

Gabr

MiddleName

A.

Affiliation

Zoology Department, Faculty of Science, Damanhur University, Egypt

Email

-

City

-

Orcid

-

First Name

Mohammed

Last Name

Elmezaien

MiddleName

S.

Affiliation

Zoology Department, Faculty of Science, Damanhur University, Egypt

Email

-

City

-

Orcid

-

First Name

Noran

Last Name

Abd Elrouf

MiddleName

A.

Affiliation

Zoology Department, Faculty of Science, Damanhur University, Egypt

Email

-

City

-

Orcid

-

First Name

Nouran

Last Name

Saed

MiddleName

M

Affiliation

Zoology Department, Faculty of Science, Damanhur University, Egypt

Email

-

City

-

Orcid

-

First Name

Nourhan

Last Name

El hantoshy

MiddleName

N.

Affiliation

Zoology Department, Faculty of Science, Damanhur University, Egypt

Email

-

City

-

Orcid

-

First Name

Yomna

Last Name

Elgendy

MiddleName

A.

Affiliation

Zoology Department, Faculty of Science, Damanhur University, Egypt

Email

-

City

-

Orcid

-

First Name

Yosry

Last Name

Hekal

MiddleName

El.

Affiliation

Zoology Department, Faculty of Science, Damanhur University, Egypt

Email

-

City

-

Orcid

-

First Name

Youssef

Last Name

Sayed

MiddleName

M.

Affiliation

Zoology Department, Faculty of Science, Damanhur University, Egypt

Email

-

City

-

Orcid

-

First Name

Aml

Last Name

Talaat

MiddleName

-

Affiliation

Zoology Department, Faculty of Science, Damanhur University, Egypt

Email

-

City

-

Orcid

-

Volume

5

Article Issue

2

Related Issue

42196

Issue Date

2023-06-01

Receive Date

2023-03-12

Publish Date

2023-06-01

Page Start

76

Page End

95

Print ISSN

2636-4093

Online ISSN

2636-4107

Article File

JMALS_Volume 5_Issue 2_Pages 76-95.pdf

PDF . 1.1MB

Link

https://jmals.journals.ekb.eg/article_299646.html

Detail API

https://jmals.journals.ekb.eg/service?article_code=299646

Order

299,646

Type

Original Article

Type Code

1,104

Publication Type

Journal

Publication Title

Journal of Medical and Life Science

Publication Link

https://jmals.journals.ekb.eg/

MainTitle

Unveiling the Hepatoprotective and Ameliorative Potential of Natural Products in Paracetamol Overdose

Details

Type

Article

Created At

25 Dec 2024