ManageChatDiscover
327540

AMELIORATED EFFECT OF COMBINED TREATMENT OF BLUEBERRY FRUIT EXTRACT AND VOGLIBOSE ON STREPTOZOTOCIN-INDUCED TYPE Ⅱ DIABETES MELLITUS IN RATS

Article

Last updated: 04 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

-

Abstract

Blueberries are rich in anthocyanins, which have been studied for many years. Interest in these compounds has grown attributing to their possible therapeutic and beneficial effects. Therefore, this study aimed to investigate the potential antioxidant, anti-inflammatory, hepatoprotective, anti-diabetic, and anti-inflammatory effects of blueberry fruit extract supplement (25% anthocyanin) in combination with aloglibtin and voglibose in streptozotocin (STZ)-induced diabetic rats.
Diabetes mellitus was induced in six groups with a single 45 mg/kg STZ injection. However, 5 of these groups were treated with alogliptin (Alog), voglibose (Vog), blueberry fruit extract (BB-fruit extract), combined treatment of (Alog + BB-fruit extract), and (Vog + BB-fruit extract), respectively, for three weeks. Serum glucose, C-peptide, lipid profile, liver enzymes, kidney enzymes, and TNF-α levels were estimated. Meanwhile, alpha-glucosidase, catalase, and superoxide dismutase (SOD) activities and malondialdehyde (MDA) levels were determined in rats' liver tissues.
All diabetic groups unveiled a significant decrease in serum glucose and C-peptide level after administering BB-fruit extract. Combination of BB-fruit extract and vog is effective in achieving sufficient glycemic control by significantly reducing inflammation, oxidative stress, hyperlipidemia, and hyperglycemia. These findings imply that this combination is an effective strategy for controlling diabetes.

DOI

10.21608/bfsa.2023.327540

Keywords

Type Ⅱ diabetes, Vaccinium uliginosum L, berries, Liver, antioxidant

Authors

First Name

Omnia

Last Name

Baheg

MiddleName

E.

Affiliation

Medicinal and Pharmaceutical Chemistry Department, National Research Centre, 33–El Behouth St., 12622, Dokki, Giza, Egypt Pharmaceutical and Drug Industries Research Division, National Research Centre, 33–El Behouth St., 12622, Giza, Egypt

Email

omniabaheg@gmail.com

City

-

Orcid

-

First Name

Mona

Last Name

Aboutabl

MiddleName

E.

Affiliation

Medicinal and Pharmaceutical Chemistry Department, National Research Centre, 33–El Behouth St., 12622, Dokki, Giza, Egypt

Email

monaaboutabl@gmail.com

City

-

Orcid

-

First Name

Nesrine

Last Name

El Sayed

MiddleName

S.

Affiliation

Pharmacology and Toxicology Department, Faculty of Pharmacy, Cairo University, Giza, Egypt

Email

-

City

-

Orcid

-

First Name

Yousreya

Last Name

Maklad

MiddleName

A.

Affiliation

Medicinal and Pharmaceutical Chemistry Department, National Research Centre, 33–El Behouth St., 12622, Dokki, Giza, Egypt

Email

yousreya_maklad@yahoo.com

City

-

Orcid

-

First Name

Sanaa

Last Name

Kenawy

MiddleName

A.

Affiliation

Pharmacology and Toxicology Department, Faculty of Pharmacy, Cairo University, Giza, Egypt

Email

sanaaakenawy@hotmail.com

City

-

Orcid

-

Volume

46

Article Issue

2

Related Issue

44483

Issue Date

2023-12-01

Receive Date

2023-04-01

Publish Date

2023-12-01

Page Start

1,325

Page End

1,339

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 46_Issue 2_Pages 1325-1339.pdf

PDF . 1.3MB

Link

https://bpsa.journals.ekb.eg/article_327540.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=327540

Order

327,540

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

AMELIORATED EFFECT OF COMBINED TREATMENT OF BLUEBERRY FRUIT EXTRACT AND VOGLIBOSE ON STREPTOZOTOCIN-INDUCED TYPE Ⅱ DIABETES MELLITUS IN RATS

Details

Type

Article

Created At

25 Dec 2024