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327623

EVALUATION OF ANTIOXIDANT, ANTIBACTERIAL, ANTALGIC AND ANTI-INFLAMMATORY PROPERTIES OF CRATAEGUS AZAROLUS

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Last updated: 04 Jan 2025

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Abstract

The purpose of this study was to examine the potential effects of a Crataegus azarolus extract on antioxidant, antibacterial, analgesic, and anti-inflammatory activities. Additionally, a phytochemical analysis was conducted to identify the chemical constituents of the extract. The antioxidant potential was assessed using DPPH, FRAP, and β-carotene assays, while the antibacterial activity was evaluated against five different microorganisms by measuring the diameter of inhibition zones. The anti-inflammatory and analgesic effects were examined by inducing paw edema with carrageenan and intraperitoneal injection of acetic acid, respectively. The results indicated that the extract exhibited strong antioxidant activity, and the highest antibacterial activity was observed against Bacillus subtilis, with an inhibition zone diameter of 18 mm.  Additionally, administering 400 mg/kg of the extract resulted in a strong inhibition of paw edema, showing a percentage reduction of 42.28% compared to the control group. Similarly, the methanolic extract (600 mg/kg) of Crataegus azarolus showed inhibition of pain caused by acetic acid in mice. The findings of the study propose that the extract has the potential to provide bioactive compounds, and that its individual constituents may act together in a synergistic manner. Therefore, Crataegus azarolus extract could be used as an alternative to synthetic anti-inflammatory and analgesic compounds in the pharmaceutical industries in the future.

DOI

10.21608/bfsa.2023.327623

Keywords

Crataegus azarolus, antioxidant, Antibacterial, antalgic, Anti-inflammatory

Authors

First Name

Zineb

Last Name

Lakache

MiddleName

-

Affiliation

Ethnobotany and natural substances laboratory, ENS Kouba, Algiers, Algeria

Email

lakache.zineb@gmail.com

City

-

Orcid

-

First Name

Hamza

Last Name

Aliboudhar

MiddleName

-

Affiliation

Functional Organic Analysis Laboratory, Faculty of Chemistry, Houari Boumediene University of Science and Technology, El Bab-Ezzouar, USTHB, Algiers, Algeria

Email

haliboudhar@yahoo.fr

City

-

Orcid

0000-0001-8761-1362

First Name

Affaf

Last Name

Laassami

MiddleName

-

Affiliation

Laboratoire de Biologie des Systèmes Microbiens , LBSM, Algiers, Algeria

Email

affaf.laassami@gmail.com

City

-

Orcid

-

First Name

Hafidha

Last Name

Metidji

MiddleName

-

Affiliation

Laboratory of Bio-Active Molecules and Valorization of Biomass, ENS kouba, Algeria

Email

-

City

-

Orcid

-

First Name

Hinda

Last Name

Hacib

MiddleName

-

Affiliation

Ethnobotany and natural substances laboratory, ENS Kouba, Algiers, Algeria

Email

lakache.zineb@yahoo.fr

City

-

Orcid

-

First Name

Hassina

Last Name

Tounsi

MiddleName

-

Affiliation

Ethnobotany and natural substances laboratory, ENS Kouba, Algiers, Algeria

Email

-

City

-

Orcid

-

First Name

Abdelkrim

Last Name

Kameli

MiddleName

-

Affiliation

Ethnobotany and natural substances laboratory, ENS Kouba, Algiers, Algeria

Email

-

City

-

Orcid

-

Volume

46

Article Issue

2

Related Issue

44483

Issue Date

2023-12-01

Receive Date

2023-04-13

Publish Date

2023-12-01

Page Start

867

Page End

880

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 46_Issue 2_Pages 867-880.pdf

PDF . 976.8kB

Link

https://bpsa.journals.ekb.eg/article_327623.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=327623

Order

327,623

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

EVALUATION OF ANTIOXIDANT, ANTIBACTERIAL, ANTALGIC AND ANTI-INFLAMMATORY PROPERTIES OF CRATAEGUS AZAROLUS

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Type

Article

Created At

25 Dec 2024