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327335

EFFORTS IN IMPROVING TABLETS’ TENSILE STRENGTH WITH A COATING SYSTEM AND BRITTLE EXCIPIENT: A REVIEW

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Last updated: 04 Jan 2025

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Abstract

Tablets are the most in-demand pharmaceutical preparation by pharmaceutical companies or users because they provide the best capabilities from all oral preparations. Maintaining the grade and quality of tablets need to be of great concern. Factors affecting the physical quality of tablets must always be evaluated, including tensile strength. Tensile strength directly affects the process of distribution, storage, disintegration, and dissolution of tablets. Tensile strength problem is often found during tablet production with the wet granulation method, in which over-granulation often occurs, especially in high-shear wet granulation (HSWG). The solution for over granulating is the addition of brittle excipients to form a strong bond when combined, thus increasing tensile strength. An ideal tensile strength may be achieved because the mechanical strength of the tablet is increased proportionally to the increased area of the bond. Another solution to increase tensile strength is by using a coating system using the Multiple Unit Pellet Systems (MUPS). The MUPS coating system often experiences problems such as caking. This problem can be overcome using a coating polymer that is stable on high RH and supports a strong tablet formulation. The solution to the tensile strength problem with the addition of brittle excipients and coating will be reviewed in this article to increase tensile strength

DOI

10.21608/bfsa.2023.327335

Keywords

Tablet, wet granulation, tensile strength, brittle excipient, coating system

Authors

First Name

Ahmad

Last Name

Ainurofiq

MiddleName

-

Affiliation

Department of Pharmacy, Sebelas Maret University, Ir. Sutami 36A, Surakarta 57126, Indonesia

Email

rofiq@mipa.uns.ac.id

City

-

Orcid

0000-0003-2880-5321

First Name

Chalimatussa'diyah

Last Name

Wuslatush Sholekah

MiddleName

-

Affiliation

Department of Pharmacy, Sebelas Maret University, Ir. Sutami 36A, Surakarta 57126, Indonesia

Email

-

City

-

Orcid

-

First Name

Dzakiyyatul

Last Name

Hanifah

MiddleName

-

Affiliation

Department of Pharmacy, Sebelas Maret University, Ir. Sutami 36A, Surakarta 57126, Indonesia

Email

dzakiyyahaniifah01@student.uns.ac.id

City

-

Orcid

-

First Name

Eka

Last Name

Susanti

MiddleName

Nurulita

Affiliation

Department of Pharmacy, Sebelas Maret University, Ir. Sutami 36A, Surakarta 57126, Indonesia

Email

ekanurulitas@student.uns.ac.id

City

-

Orcid

-

First Name

Meila

Last Name

Suryaningrum

MiddleName

Tunjung

Affiliation

Department of Pharmacy, Sebelas Maret University, Ir. Sutami 36A, Surakarta 57126, Indonesia

Email

meila_17@student.uns.ac.id

City

-

Orcid

-

First Name

Meyliana

Last Name

Kusumawardhani

MiddleName

Adhitya

Affiliation

Department of Pharmacy, Sebelas Maret University, Ir. Sutami 36A, Surakarta 57126, Indonesia

Email

adhityameyliana@student.uns.ac.id

City

-

Orcid

-

Volume

46

Article Issue

2

Related Issue

44483

Issue Date

2023-12-01

Receive Date

2023-02-06

Publish Date

2023-12-01

Page Start

669

Page End

682

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 46_Issue 2_Pages 669-682.pdf

PDF . 1.3MB

Link

https://bpsa.journals.ekb.eg/article_327335.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=327335

Order

327,335

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

EFFORTS IN IMPROVING TABLETS’ TENSILE STRENGTH WITH A COATING SYSTEM AND BRITTLE EXCIPIENT: A REVIEW

Details

Type

Article

Created At

25 Dec 2024