Two hundred fifty of unsexed Seven-days-old Japanese quail (JQ) were randomly distributed into 5 dietary treatments with 5 replicates each to investigate the effect of olive pomace (OP) without or with enzyme (EZ) on productive performance, nutrients digestibility and some blood parameters in Japanese quail. Dietary treatments were:  The 1^st group fed a basal diet without olive pomace as a control. JQ in 2^nd and 3^rd groups were fed diets contained 5% OP either without or with EZ addition, respectively, while those in 4^th and 5^th   groups were fed diets contained 10% OP either without or with EZ addition, respectively. Body weight (BW), Body weight gain (BWG), feed intake (FI), feed conversion ratio (FCR), apparent digestibility, production index, economical efficiency, carcass traits and blood parameters were investigated. Results indicated that JQ fed diets contained 5% or 10% OP with EZ addition exhibited significantly (p ≤ 0.05) higher values of BW, BWG, FI, economical efficiency, production index and better FCR, digestibility of dry matter and crude protein as well as dressing carcass%, serum T3 and antioxidant enzymes compared to the corresponding groups fed diets contained 5% or 10% OP without EZ, without difference compared to control group. On the other hand, JQ fed diets contained 5% or 10% OP with or without EZ addition decreased significantly (p ≤ 0.05) serum total protein, albumen and globulin compared to control group. Also, group fed diet contained 10% OP without EZ recorded lower (p ≤ 0.05) value of total antioxidant capacity, glutathione peroxidase as well as digestibility of crude fiber and ether extract compared to all others treatments. It can be concluded that EZ supplementation in Japanese quail diets contained OP up to 10 % could be used safely without adverse effect on growth performance and up to 5% with adding EZ to achieve optimum growth performance, economic efficiency and digestibility of nutrients during growing period.