Chemical analysis for forty surface water samples collected from some water drains at El-Gharbia and Kafer El-Sheikh governorates was carried out to check for heavy metal pollution. The results indicated high heavy metal contents in water samples ranged 0.480-0.610 ppm for lead, 0_450-0.810 ppm for mercury and 0.770-0.890ppm for arsenic. No fish samples could be captured from El-Mahala El-Kobra. Twenty Clarias lazera fish samples collected from El-Hammol at Kafer El-Sheikh govemorate were used for determination of the heavy metal residues in their tissues. The quantitative analysis of these heavy metal residues in their liver, kidney and muscles revealed the presence of high levels of Hg, As and Pb in liver (5.22, 1.93 and 1.72 ppm, respectively), followed by kidney (2.30, 1.08 and 0.90 ppm, respectively) and muscles (1.78, 0.40 and 0.32 ppm, respectively), of the same fish.