ABSTRACT
In order to investigate the anti-urolithic effects of Cymbopogon proximus (halfa-bar) and Petroselinum sativum (parsley) extracts, ethylene glycol-induced renal stones was assessed in male albino rats at a dose of 500 mg/kg body weight/day and compared with a dose of 750 mg/kg body weight/day of cystone as a reference drug. Ethylene glycol (0.75% v/v) and ammonium chloride (1% w/v) in drinking water can trigger urolithiasis. Animals were divided into six groups: normal control , positive control , standard control , halfa-bar group, parsley group, and plants mixture (1:1). Plant extract therapy changed all of the increased biochemical indicators, including serum (creatinine, urea, and uric acid). In addition, the plant extract groups normalized urine pH, provided a closer look at calcium oxalate crystals under a microscope, and more effectively supported kidney function. Microscopic and histopathological results confirmed and showed that the potential preventive and therapeutic plant extracts inhibit kidney stones. Finally, the plant extracts have a combination of phytochemicals , antioxidant, diuretic, urine alkalinizing, and calcium-lowering actions that act as an anti-urolithiasis impact against calcium oxalate stones. The results confirmed that a mixture of the two plants was superior in potency, followed by C. proximus and then P. sativum.