For thousands of years, nature served as a source for therapeutic substances, and a remarkable number of modern drugs have been identified from natural sources. Since the beginning of time, higher plants have been important in the preservation of human health as sources of therapeutic chemicals. The pharmaceutical industry's drug development programs heavily rely on natural products, which are the source of more than 50% of all contemporary clinical medications. One of the biggest issues facing many countries, particularly developing countries, is the problem of expensive and insufficient medicine supplies. So, one of the key options to solve this problem is traditional plant-based medicine. Therefore, it is important to protect these plants and their genetic heritage. A total of 100 species of economical and medicinal importance were recorded in Wadi Feiran, South Sinai, Egypt. Families with the most representation in the study area were Poaceae, Asteraceae, and Amaranthaceae. The flowering branches, and leaves are the most used plant parts in addition to the whole plant. The most medicinal and economical uses of the recorded species include grazing, fuel wood, aromatic sources, diuretics, analgesics for stomach and abdominal pain, treatment wounds, skin diseases and aromatic sources. Many of these species have multi medicinal and economic benefits.