Field experiments were carried out at Ashmoun district, Menofia Governorate to study the efficacy of certain pre-emergence (PRE) and post-emergence (POST) herbicides in controlling weeds in dry bean crop compared to hang hoeing and the untreated check during 2019 and 2020 seasons. Herbicides used were pendimethalin, halosulfuron-methyl, s-metolachlor, bentazon, oxyfluorfen and fluazifop-p- butyl, hand hoeing (16 and 27) days after sowing (DAS) and the untreated check. Results illustrated that the predominant weed species in dry bean field were, Amaranthus cruentus, Chenopodium album, Portulaca oleracea and Sonchus oleraceus as broad-leaved weeds, while Cyperus longus, Setaria verticillata and Echinochloa colonum were the predominant grassy weeds. Results indicated that oxyfluorfen (PRE) and halosulfuron-methyl (POST) treated plots caused visible injury to dry bean plants. Generally, all weed control treatments significantly reduced weed biomass (fresh weight of weeds g m^-2) of the predominant weeds in comparison with the untreated. Maximum reduction in fresh weight of weeds, highest weed control efficiency (WCE), highest bean seeds and highest net benefits were recorded in POST halosulfuron-methyl + bentazon tank mix at 15 + 240 g fed.^-1 followed by hand hoeing treatment and pendimethalin fb bentazon (PRE fb POST at 455+ 240 g a.i. fed^-1) during the two studied seasons.