Liver diseases are among the most challenging healthcare problems worldwide. Thus, there has been a need to explore alternative therapies to chemotherapy drugs that have long been used to treat liver patients, the use of which has been associated with many side effects, in addition to the significant financial cost, which often leads to patient non-compliance. This study was conducted to explore the Effect of three plant parts that result as wastes from food processing, namely red onion skin, banana peels and apricot kernel powders, on hepatotoxicity induced by carbon tetrachloride in rats. Compared with the normal control group rats, the CCl₄ treated rats showed significant (p≤0.05) decreases in different biological parameters, including BWA, FI and FER, by the rate of -35.16, -33.31 and -31.08%, respectively. Also, biochemical parameters such as serum liver enzyme activities AST, ALT and ALP were significant (p≤0.05) elevated by the rate of 107.92, 102.71 and 135.64%, respectively. For immunological parameters, Alb was significant (p≤0.05), decreased by -37.61, and TNF-α increased by 102.84%. Also, oxidative stress is recorded in the blood through a decrease in the level of antioxidants (GSH and GSSG) and increased oxidants (MDA and NO₂).  All of those parameters indicated liver injuries by CCl₄. Whereas animals treated with the selected plant parts (red onion skin powder, ROSP, banana peel powder, BBP, apricot kernel powder, AKP and their mixture) showed significant (p≤0.05) improvements in all previous biological, biochemical, and immunological parameters as well as reduce the oxidative stress markers which indicating the protection against hepatic cell damage. The highest amelioration effects against CCl₄-induced hepatotoxicity were recorded in rats treated with a mixture of plant parts, followed by ROSP, BPP and AKP groups, respectively. In conclusion, the selected plant parts effectively protected against CCl₄-induced hepatotoxicity. Therefore, we recommended powders of these plant parts in concentrations of up to 5% (w/w), an amount to be included in our daily live diets, drinks and food supplements.