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346688

ERCC1 rs11615 Single Nucleotide Polymorphism in Bladder Cancer Patients and Safety Outcomes of Cisplatin-Based Chemotherapy

Article

Last updated: 04 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Clinical pharmacy and therapeutics.

Abstract

This is a pilot single-center retrospective cohort research study aimed to investigate the relationship between single nucleotide polymorphism (SNP) of excision repair cross-complementation group 1 (ERCC1) rs11615 and the safety outcomes of cisplatin-based adjuvant chemotherapy in post-cystectomy bladder cancer patients. The study involved 25 patients with muscle invasive bladder cancer who were admitted to Urology and Nephrology Center (UNC), Mansoura University, Egypt between January and December 2016. The study tried to reveal the association between SNP rs11615 in ERCC1 gene and the change from baseline characteristics in a median of 96 weeks follow-up in blood, renal and hepatic biochemical parameters. Univariate analysis of the association between rs11615 and post-chemotherapy changes in uric acid and hemoglobin levels showed statistically significant relationship. These findings hint at possible genetic influences in response to chemotherapy, necessitating further research to understand the mechanisms and potential clinical implications. This could lead to personalized treatment plans enhancing patient care and outcomes.

DOI

10.21608/jampr.2024.271205.1063

Keywords

ERCC1, rs11615, Bladder cancer, Chemotherapy, Safety Outcomes

Authors

First Name

Khaled

Last Name

Kotb

MiddleName

M

Affiliation

Clinical Pharmacy and Pharmacy Practice Department, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt, 35516

Email

k.kotb@mans.edu.eg

City

-

Orcid

-

First Name

Moetaza

Last Name

Soliman

MiddleName

M

Affiliation

Clinical Pharmacy and Pharmacy Practice Department, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.

Email

moetaza13@yahoo.com

City

-

Orcid

0000-0002-8651-9385

First Name

Amira

Last Name

Awadallah

MiddleName

-

Affiliation

Center of excellence for Genome and Cancer Research, Urology and Nephrology Center, Mansoura University, Egypt

Email

a.awadallah@mans.edu.eg

City

-

Orcid

-

First Name

Asmaa

Last Name

Ahmed

MiddleName

E

Affiliation

Genetics Research Unit, Faculty of Medicine, Delta University for Science and Technology, Gamasa, Egypt

Email

dr-asmaaelsayed@hotmail.com

City

-

Orcid

-

First Name

Hassan

Last Name

Abol-Enein

MiddleName

-

Affiliation

Urology and Nephrology Center, Mansoura University, Mansoura, Egypt

Email

hassan@mans.edu.eg

City

-

Orcid

-

First Name

Mohamed

Last Name

Shams

MiddleName

E E

Affiliation

Clinical Pharmacy and Pharmacy Practice Department, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt

Email

shams@mans.edu.eg

City

-

Orcid

-

Volume

5

Article Issue

1

Related Issue

46784

Issue Date

2024-03-01

Receive Date

2024-02-18

Publish Date

2024-03-01

Page Start

42

Page End

48

Online ISSN

2636-4158

Article File

JAMPR_Volume 5_Issue 1_Pages 42-48.pdf

PDF . 355.8kB

Link

https://jampr.journals.ekb.eg/article_346688.html

Detail API

https://jampr.journals.ekb.eg/service?article_code=346688

Order

346,688

Type

Original Article

Type Code

855

Publication Type

Journal

Publication Title

Journal of Advanced Medical and Pharmaceutical Research

Publication Link

https://jampr.journals.ekb.eg/

MainTitle

ERCC1 rs11615 Single Nucleotide Polymorphism in Bladder Cancer Patients and Safety Outcomes of Cisplatin-Based Chemotherapy

Details

Type

Article

Created At

24 Dec 2024