Fifteen dairy Shami goats (5 per group) were fed three different DCAD levels, (T1) control group contain a high DCAD level feeding positive DCAD diet (+215 mEq/kg DM), (T2) fed (zero DCAD) and (T3) fed  a low DCAD level feeding negative DCAD (–150 mEq/Kg DM). Feeding positive DCAD diet (T1) resulted in higher (P <0.05) plasma pH than dairy Shami goats fed the negative dietary DCAD. Plasma calcium, phosphorus and Magnesium concentration increased significantly (P <0.05) with decreasing DCAD level. The highest significant (P < 0.05) plasma calcium, phosphorus and Magnesium level was recorded for group (3) (-150 mEq/kg DM) and the lowest was obtained with group (1) (+215 mEq/Kg DM). Plasma parathyroid hormone (PTH) concentration decreased significantly (P < 0.05) with decreasing DCAD. The lower DCAD value was recorded with negative DCAD and increased significantly with (zero DCAD), While, the higher were recorded with positive DCAD group. The negative DCAD fed to group (T3) showed significantly (P<0.05) the highest milk yield followed by group (T2) fed (Zero DCAD), while the control group (T1) positive DCAD had the lowest milk yield. Anionic salts didn't affect milk total solid (TS), Ash, Moisture and  solid not fat (SNF), However milk protein and  fat were increased in treatment (3) when compared with other treatments. The group (T1) fed positive DCAD (+215 mEq/Kg DM) showed significantly (P<0.05) the highest somatic cell count and lactose followed by group (T2) fed (zero DCAD), while, negative DCAD (-150/mEq/Kg DM) fed group (T3) had the lowest. Based on the study, Lowering DCAD beyond (-150) mEq/kg DM improves the lactation performance and some physiological parameters of dairy Shami goats.