Providing human food has become the biggest challenge during climate change. Two Field experiments were conducted to evaluate the effect of some friendly materials i.e., seaweed extract at 100 and 200 ml/l, Jasmonic acid at 100 and 200 mg/l, Brassinolide at 100 and 200 mg/l and salicylic acid at 100 and 200 mg/l on growth, growth performance, flowering, fruit yield, fruit quality, chemical compositions and bio constituents indicators for heat stress tolerance of Tomato plants (Solanum lycopersicum Mill.) grown under heat stress conditions. Foliar application of tomato plants with seaweed extract at 200 ml/l significantly increased plant height, number of leaves, number of branches /plant, total leaf area cm²/plant, leaves and shoots dry weights and leaves/ shoots ratio during 2021 and 2022 seasons. Flowering characteristics applied were increased with different treatments during both seasons. In addition, yield and yield components were increased with different applications during both seasons. The superior was the seaweed extract at 200 ml/l during the first and second seasons. Plant chemical compositions i. e, (N, P, K, Fe, Zn) Also, some bio constituents stress indicators (proline contents, total phenols, total free amino acids and total indoles) were increased with different applications especially seaweed extract at 200 ml/l during both seasons. Using friendly material especially seaweed extract can be exploited for high growth, mineral, fruit yield and yield components and fruit chemical quality under heat stress conditions.