Reprocessing food and agriculture waste (FAW) is of great interest, these residues can be converted into fruitful products, and lactic acid bacteria (LAB) are at the forefront of this approach. Therefore, the present study is aimed at exploring LAB bioconversion potential. Herein, Lactiplantibacillus plantarum MC39 (MZ769311) was used for the fermentation assay. The inhibitory effect against multi-drug resistant Klebsiella pneumoniae W8(MZ769363) and Enterobacter hormaechei U25 (MZ769310) was used as indicator for lactic acid production. Rice bran, wheat bran, alfalfa hay, reed straw, potato peels, banana peels, orange peels, and fava bean peels were used as fermentation substrates with different carbohydrate contents. The results showed that the maximum inhibitory effect was attained when orange peels were used after 96h of fermentation, followed by fava bean peels after 72h of fermentation. These findings suggest that the carbohydrate content of fermentation residues has a significant effect on lactic acid production, and orange peels could be a suitable feedstock substrate in solid state fermentation for lactic acid production that could be used as an antimicrobial agent inhibits MDR Gram-negative pathogens.