Feline enteritis has significant clinical issues that have an impact on their health. This study was carried out on 30 cats having different types of enteritis affections including viral, bacterial and parasitic enteritis. The purpose of the study was to assess the clinical, hematological, and biochemical alterations in cats with various forms of enteritis diseases. The most prevalent clinical signs seen in all forms of enteritis were diarrhea, vomiting, dehydration, Anorexia. Hematological changes revealed significant reduction in hemoglobin content and red blood cell count than control values in viral and bacterial enteritis. WBCs count and granulocytes % were significantly increased in bacterial enteritis. There was significant decrease in lymphocytes and granulocytes% in viral enteritis and significant increase of eosinophils % in parasitic enteritis. Total protein, globulin, ALT, ALP, and AST, as well as BUN and creatinine, were significantly increased and significant decrease in Ca, P, Na, Cl and K ions in different types of enteritis. There was significant decrease in antioxidant enzymes levels including GSH-Px and SOD and significant increase in MDA and inflammatory cytokines including IL2 and IL6 and acute phase proteins including HP and CRP in all affections. These results highlight the complexity of feline enteritis and the demand for specialized treatment strategies to meet the wide range of clinical, hematological and biochemical changes.