Neurotoxicity  is  commonly  associated  with  the  central  and/or  peripheral  nerve  systems structural damage.  It happens when a chemical  interferes with the normal functioning of the nervous  system,  potentially  resulting  in  the death  of neurons  transmitting  and  informationprocessing. The purpose of this study was to investigate the effect  of  aluminum chloride (AlCl₃) induced  neurotoxicity  in  mice.  Forty  mice  were  allocated  into  two  equal  groups.  Group  1(Normal  control),  which  fed  a  regular laboratory  diet  for  four  weeks.  Group  2  (Aluminum chloride) rats received AlCl₃ orally at a dose of (8.5 mg/kg/day) for four weeks. The obtained results revealed a  significant increase in  brain tissue  amyloid beta,  nitric  oxide and in serum cortisol,  complement C3 and C4 concentrations, while brain tissue  SOD and CAT activities were  markedly  decreased  in  AlCl₃  treated  mice  as  compared  with  normal  control.   In conclusion,  AlCl₃  has  toxic  and  harmful  effects  with  noticeable  oxidative  stress  and inflammation.