The present research was planned to evaluate the protective effect of propolis water extract against cisplatin hepato-renal toxicity. Twenty-four male albino rats were divided into 4 equal groups . G1(control) administered water only ,G2(propolis) administered (100 mg extract of propolis/kg.b.wt.) orally by stomach tube once daily dose for 14 days, G3(cisplatin) administered once dose intraperitoneal (7.5 mg cisplatin/kg.b.wt.) at day 10th of experiment , G4(cisplatin+propolis) administered like G2 and G3.The serum biochemical analysis in cisplatin group revealed increase in AST, ALT, ALP, cholesterol, triglyceride, LDL- cholesterol, urea, and creatinine concentrations and decreased total protein and albumin concentration. Moreover, cisplatin- treated rats significantly increases of MDA level and decreased SOD and CAT levels in hepatic and renal tissue compared to control group. Administration of propolis (100 mg extract of propolis/kg.b.wt.) orally by stomach tube one hour before the second drug which is once intraperitoneal (7.5 mg cisplatin/kg.b.wt.) at day 10th of experiment (day number ten of experiment which continued 14 days) reversed induced hepatorenal damage of cisplatin group by exerting antioxidant and anti-inflammatory effect. Histopathological and immuno-histochemical examination showed the hepatorenal damage induced by cisplatin was attenuated by propolis. In conclusion, propolis may help to lessen the hepatorenal damage induced by cisplatin via its antioxidant and antiapoptotic activities.