343644

Evaluation of different adjuvants to the inactivated PPR vaccine

Article

Last updated: 04 Jan 2025

Subjects

-

Tags

Microbiology

Abstract

The Peste des petits ruminant (PPR) is a viral devastating illness of sheep and goats resulting in huge losses to the economy and its control mainly depends on successful vaccination of susceptible hosts. The use of inactivated vaccine is preferable in non-endemic regions. Determination of the best adjuvant to the inactivated PPR vaccine induces the highest vaccine potency. Preparation of inactivated PPR virus infected fluid obtained from infected Vero cell by binary ethylene amine and divided it into three portions adjuvant by Montanide -01 gel; Montanide oil ISA 206 and Carbomer then subjected to quality control testing. All of the three prepared inactivated PPR vaccine formulae were found to be free from foreign contaminants; safe and highly immunogenic inducing nearly similar antibody titers in vaccinated sheep remaining up to 28 weeks post vaccination and suggested to be of longer duration. Each of Mantonide-01 gel; Montanide oil ISA 206 and Carbomer could be recommended to use as an adjuvant to the inactivated PPR vaccine with regard to the cost of vaccine production.

DOI

10.21608/bvmj.2023.247497.1747

Keywords

Peste des petits ruminants (PPR) Virus, Potency, Inactivation, Adjuvant

Authors

First Name

Manal

Last Name

Hussein

MiddleName

Abdelaziz

Affiliation

1 Department of Virology, Faculty of Veterinary Medicine, Benha University, Egypt 2 Veterinary Serum and Vaccine Research Institute (VSVRI), Abbasia, Cairo, Egypt

Email

mnaziz2017@gmail.com

City

-

Orcid

-

First Name

Gabr

Last Name

Elbagory

MiddleName

Fikry

Affiliation

Department of Virology, Faculty of Veterinary Medicine, Benha University, Egypt

Email

gabr.albagory@fvtm.bu.edu.eg

City

mostohor tukh

Orcid

0000-0002-2204-064X

First Name

Mohammad

Last Name

Khodier

MiddleName

Hassan

Affiliation

Veterinary Serum and Vaccine Research Institute (VSVRI), Abbasia, Cairo, Egypt

Email

profdrkhodeir@gmail.com

City

Nasr city

Orcid

-

Volume

45

Article Issue

2

Related Issue

46335

Issue Date

2023-12-01

Receive Date

2023-11-09

Publish Date

2023-12-01

Page Start

168

Page End

172

Print ISSN

1110-6581

Online ISSN

2974-4806

Link

https://bvmj.journals.ekb.eg/article_343644.html

Detail API

https://bvmj.journals.ekb.eg/service?article_code=343644

Order

343,644

Type

Original Article

Type Code

812

Publication Type

Journal

Publication Title

Benha Veterinary Medical Journal

Publication Link

https://bvmj.journals.ekb.eg/

MainTitle

Evaluation of different adjuvants to the inactivated PPR vaccine

Details

Type

Article

Created At

24 Dec 2024