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343484

Ameliorative Effect of Novel Nanocompound against Oxidative Stress- Induced Brain Toxicity in Mice

Article

Last updated: 04 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Biochemistry

Abstract

This study investigates the antioxidant properties of pH-responsive chitosan-based poly (acrylamide/acrylic acid) hesperidin (Cs/P(AAc/AAm)/HSP) Nanogel in AlCl3+NaF-intoxicated mice brain tissues as a pre-treatment and post-treatment agent. Fifty adult male Albino mice were used in our study, and were divided equally into 5 groups of (Ⅰ) normal control, (Ⅱ) Cs/P(AAc/AAm)/HSP, (Ⅲ) AlCl3+NaF, (Ⅳ) pre-treatment (prophylaxis), (Ⅴ) post-treatment (therapeutic). We used the colorimetric technique to detect the concentrations of MDA and GSH as well as the activity of SOD and GPx. AlCl3+NaF induced severe neurotoxicity and oxidative stress in mice brain tissue, manifested by the marked changes in the studied parameters. Either pre- or post-Cs/P(AAc/AAm)/HSP oral administration ameliorated these changes, as demonstrated by the significant reduction in MDA concentration, and increased GSH levels. Additionally, Cs/P(AAc/AAm)/HSP restored the activity of SOD and GPx enzymes, indicating mitigation of the induced oxidative stress. Our findings from this study clearly showed the antioxidant potential of Cs/P(AAc/AAm)/HSP either as a prophylactic or therapeutic agent against AlCl3+NaF-induced brain damage.

DOI

10.21608/bvmj.2023.255548.1765

Keywords

fluoride, Aluminum, Hesperidin, Neurotoxicity

Authors

First Name

Nora

Last Name

Deiab

MiddleName

Samy

Affiliation

Biochemistry and Molecular Biology Department, Faculty of Veterinary Medicine, Benha University, Benha, Al Qalyubiyah, Egypt

Email

nora.diab20@fvtm.bu.edu.eg

City

-

Orcid

-

First Name

Ahmad

Last Name

Kodous

MiddleName

Shehata

Affiliation

Radiation Biology Department, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority, Cairo, P.O. Box 13759, Egypt. Molecular Oncology Department - Cancer Institute (WIA), 38 Sardar Patel Road

Email

ahmad.kodous@eaea.sci.eg

City

-

Orcid

-

First Name

Mohamed

Last Name

Mahfouz

MiddleName

-

Affiliation

Biochemistry and Molecular Biology Department, Faculty of Veterinary Medicine, Benha University, Benha, Al Qalyubiyah, Egypt

Email

drm_mahfouz@yahoo.com

City

-

Orcid

-

First Name

Alshaimaa

Last Name

Said

MiddleName

Mohammed

Affiliation

Biochemistry and Molecular Biology Department, Faculty of Veterinary Medicine, Benha University

Email

alshaimaa.said@fvtm.bu.edu.eg

City

Benha

Orcid

0000-0001-5655-9514

First Name

omayma

Last Name

abouzaid

MiddleName

ahmed

Affiliation

Biochemistry and Molecular Biology Department, Faculty of Veterinary Medicine, Benha University, Benha, Al Qalyubiyah, Egypt

Email

omayma.abozaid@fvtm.bu.edu.eg

City

Benha

Orcid

-

Volume

45

Article Issue

2

Related Issue

46335

Issue Date

2023-12-01

Receive Date

2023-12-14

Publish Date

2023-12-01

Page Start

61

Page End

65

Print ISSN

1110-6581

Online ISSN

2974-4806

Article File

BVMJ_Volume 45_Issue 2_Pages 61-65.pdf

PDF . 403.9kB

Link

https://bvmj.journals.ekb.eg/article_343484.html

Detail API

https://bvmj.journals.ekb.eg/service?article_code=343484

Order

343,484

Type

Original Article

Type Code

812

Publication Type

Journal

Publication Title

Benha Veterinary Medical Journal

Publication Link

https://bvmj.journals.ekb.eg/

MainTitle

Ameliorative Effect of Novel Nanocompound against Oxidative Stress- Induced Brain Toxicity in Mice

Details

Type

Article

Created At

24 Dec 2024