Polycystic Ovary Syndrome (PCOS) is one of the most frequent conditions, which affects both metabolic and reproductive systems causing irregular menstrual cycles, chronic anovulation, and hyper-androgenism. Accordingly, the objective of the study is to investigate the effect of Cinnamon zeylanicum (CZ) Hydroalcoholic extract on oxidative injury and some biochemical changes in adult rats with PCOS. Fifty female rats, aged 3 months, and weighing on average 200–250g, were equally divided into 5 groups. Group I (Normal control): Rats received normal diet without medications, Group II (letrozole-induced PCOS): Rats were orally administrated 1mg/kg b. wt. /day of letrozole for 4 weeks, Group III (Metformin treated): After 4 weeks of letrozole administration, rats were orally treated with 150mg/kg b. wt./day of metformin for 30 days, Group IV (CZ treated): Rats were administrated letrozole as group II and orally treated with 200mg/kg b. wt./day of Hydroalcoholic extract of CZ for 30 days, Group V (metformin + CZ treated): Rats were administrated letrozole and treated daily with metformin and CZ for 30 days as group III+IV. The results revealed that diseased rats had significant alterations in serum estrogen and progesterone levels and marked elevation of serum total cholesterol, triacylglycerol concentrations, and oxidative injury biomarkers. Treatment with Hydroalcoholic extract of CZ to PCOS rats caused remarkable amelioration in all previous parameters.
Conclusively, the Hydroalcoholic extract of CZ treatment ameliorates oxidative injury caused by letrozole enhances the antioxidant defense system, and prevents lipid peroxidation.