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Prospective Ameliorative Activity of Neem (Azadirachta Indica) on Iron Oxide Nanoparticle-Induced Multiple Organ Injury via Attenuating TNF-α Pathway

Article

Last updated: 24 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Forensic medicine and toxicology

Abstract

Neem trees (Azadirachta indica) have received a lot of academic interest recently because of their strong antioxidant and anti-proliferative capabilities. In this study, we evaluated the potential alleviating effect of neem on Fe2O3 NP -induced damage in brain, heart, and testis. Twenty-eight male albino rats were divided into four equal groups at random. The control group was given D.W orally for 45 days, Neem group was given 200 mg/kg/day orally for 45 days, Fe2O3 NP group was given 60 mg/kg of Fe2O3 NP I/P at the 31th-45th day, Fe2O3 NP +Neem group was given 200 mg/kg day of neem orally for 45 days + 60 mg/kg of Fe2O3 NP IP at the 31th–45th day. In the present investigation, histopathological examination of brain, heart, and testis sections revealed cellular degeneration and necrosis after Fe2O3 NP exposure. Also, TNF-α expressions were considerably elevated. Neem pr-treatment maintain tissue architecture in Fe2O3 NP-intoxicated rats. Our findings proved that neem have a potential protective impact against cellular damage induced by Fe2O3 NP through its anti-inflammatory, antiapoptotic, and antioxidant effects.

DOI

10.21608/bvmj.2023.189946.1636

Keywords

Fe2O3 NP, Neem, histopathology, Immunohistochemistry

Authors

First Name

radwa

Last Name

amin

MiddleName

Amin

Affiliation

Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Benha University, Egypt. Menoufia University Hospital, Faculty of Veterinary Medicine, Sadat City University, Egypt.

Email

radwaaminnasef32@gmail.com

City

berkt al sabaa

Orcid

29101011705227

First Name

Nabila

Last Name

Abd Elaliem

MiddleName

Mahmoud

Affiliation

Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Benha University, Egypt.

Email

nabila.salam@fvtm.bu.edu.eg

City

-

Orcid

26512271701984

First Name

Ahmed

Last Name

Abdeen

MiddleName

Abdel Hafez

Affiliation

Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Benha University, Egypt.

Email

ahmed.abdeen@fvtm.bu.edu.eg

City

benha

Orcid

28109281702154

First Name

Samar

Last Name

Ibrahim

MiddleName

Saber

Affiliation

Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Benha University, Egypt.

Email

samar.mohamed@fvtm.bu.edu.eg

City

-

Orcid

0000-0001-5530-9521

First Name

Moamen

Last Name

Elsafty

MiddleName

Hussien

Affiliation

Department of Pharmacology, Faculty of Veterinary Medicine, Benha University, Egypt.

Email

moamen.alsafti20@fvtm.bu.edu.eg

City

benha

Orcid

-

First Name

Ebtssam

Last Name

Beder

MiddleName

Gamal

Affiliation

Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Benha University, Egypt.

Email

ebtssam.beder@fvtm.bu.edu.eg

City

-

Orcid

-

Volume

44

Article Issue

1

Related Issue

40949

Issue Date

2023-04-01

Receive Date

2023-03-01

Publish Date

2023-04-01

Page Start

55

Page End

60

Print ISSN

1110-6581

Online ISSN

2974-4806

Article File

BVMJ_Volume 44_Issue 1_Pages 55-60.pdf

PDF . 2.0MB

Link

https://bvmj.journals.ekb.eg/article_296319.html

Detail API

https://bvmj.journals.ekb.eg/service?article_code=296319

Order

296,319

Type

Original Article

Type Code

812

Publication Type

Journal

Publication Title

Benha Veterinary Medical Journal

Publication Link

https://bvmj.journals.ekb.eg/

MainTitle

Prospective Ameliorative Activity of Neem (Azadirachta Indica) on Iron Oxide Nanoparticle-Induced Multiple Organ Injury via Attenuating TNF-α Pathway

Details

Type

Article

Created At

24 Dec 2024