The aim of the current study was to assess the hepato-protective role of Glycyrrhiza glabra (G. glabra) on hepatic coccidiosis in experimentally infected rabbits. Forty New Zealand rabbits were used in this study. Rabbits were randomly divided into four groups:G1; rabbits supplemented with Glycyrrhiza glabra extract ,G2; the protected group was administrated diclazuril at a dose of (1mg/kg B.W)for a week before infection,G3;was kept as infected+nontreated(CP) and G4 was kept non-treated and non-infected(CN). Animals in G1 were supplemented with a daily dose of 300 mg/kg BW which began one week before infection and continued daily till the end of the experiment. On the 7th day of the experiment, all groups except G4 were orally infected with 104 sporulated oocysts of Eimeria stiedae per rabbit using a stomach tube. Rabbits in all groups were examined for clinical signs, body weight, fecal oocysts count, hematological and biochemical parameters (liver, and kidney function), as well as histopathological lesion. The results showed a significant enhancement in clinical signs and body weight with a highly significant reduction in oocysts shedding, as well as a significant improvement in CBC and serum liver and kidney parameters in the botanical plant and diclazuril groups (G1, G2) when compared to infected control group. Finally, G. glabra has potential protective activity against E. stiedae in rabbits and could be applied as a safe and effective alternative product to protect rabbit from hepatic coccidiosis.