The use of medicinal plants from the traditional African pharmacopoeia in the treatment of various diseases has been known for a long time, and the positive effects of this phytotherapy are no longer in question. However, these practices are based on empiricism. The methanolic extract of the leaves of Artemisia herba-alba has analgesic and anti-inflammatory properties that justify its traditional use. This study evaluates the anti-inflammatory and antibacterial properties of the methanolic leaf extract of Artemisia herba-alba. The negative control and test groups received 40 mg/kg of the extract. The anti-hematogenic effects of the extract showed a significant decrease in carrageenan-induced paw edema at 1 and 3 hours, as well as dextran-induced inflammation, compared to the control. In addition, there was inhibition of xylene-induced ear edema with a significant reduction compared to the control (p<0.05). The bacterial activity was determined on five bacterial strains: Klebsiella pneumoniae ATCC700603, Citrobacter freindii ATCC8090, Salmonella typhii ATCC13311, Enterobacter coloacae ATCC13047 and Staphylococcus aureus ATCC25923, according to the in vitro agar diffusion method (aromatogram). Our extract would therefore be an advantageous source of improved traditional medicine that is accessible and less expensive for people.