Background: Worldwide, harmless and proper drug administration is an essential issue associated with a patient's life safety and the value of care. Nurses support the healthcare system and dynamically care for patients. Aim: To determine the effect of evidence-based educational intervention regarding high-alert medications on critical care units ‘nurses & patients clinical outcomes. Setting: The study was conducted at the critical care units affiliated with a Bani Sueif University Hospital. Method: A quasi-experimental research design was used using a pretest-posttest approach. A convenience sample of 60 nurses and 60 patients was selected to attain the aim of the current study. The results revealed highly statistically significant differences regarding total mean scores of nurses' knowledge and practice pre- and post-implementation of evidence-based educational intervention. Also, there was an improvement in the total mean scores of the patients' outcomes regarding HAM. Conclusion: Here's a rephrased version of your text: The evidence-based educational intervention shows a significant increase in the overall average knowledge and practice scores among nurses. Additionally, the intervention showed a notably positive impact on patient clinical outcomes in critical care settings regarding the application of the HAM. Recommendations: It is advised that nurses incorporate HAM into their care practices following evidence-based guidelines. Nurses should also engage in both internal and external training programs, as well as attend and participate in conferences, to continually update their knowledge and practices related to evidence-based HAM.