The prevalence and chemotherapy of sarcoptic mange in buffaloes was studied at Civil Veterinary Hospital, Faisalabad. Of 1377 buffalo accessions to Civil Veterinary Hospital over a period of one year (January 1996 to December 1996), sarcoptic mange was recorded in 96 6.96%) animals. The prevalence was significantly higher (83.3%) among the animals below the age of one year than in animals over sac year (16.6%) . Sex had no bearing on the prevalence of the disease. The winter season was mostly associated with the occurrence of the disease (16.38%) followed by spring (6.38%) autumn (5.78%) and summer (0.36%). A single subcutaneous injection of Ivermectin B1 Hospital, fvotek-Star laboratories) at the rate of 200 ug/kg affected a 100% clinical and parasitological cure within 20 days.