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377377

EFFECT OF THE FUNGICIDE (TRI-MILTOX FORT) ON SOME REPRODUCTIVE ASPECTS IN FEMALE RATS

Article

Last updated: 03 Jan 2025

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Subjects

-

Tags

Theriogenology / reproductive technology

Abstract

Two main experiments were carried out to investigate the effect of chronic low dose oral administration of the fungicide Tri-Miltox Fort (TMF) on female reproduction in rats. In the 1st experiment, 24 non pregnant mature female rats were divided into 2 equal groups, the 1st one was kept as a control while . the 2nd one was given water containing 0.5 g/liter of the fungicide for a period of 2 months, thereafter, half of each group was sacrificed and the remaining half was allowed to drink tap water only for a period of another month then sacrificed. Blood and tissue samples were collected and subjected to biochemical, pathological and chromosomal studies.in the the 2nd experiment, 14 pregnant rats, were divided into 2 groups, the 1st one (N=6) was kept as a control while, the 2nd one (N=8) Received the above mentioned dose of the fungicidal during days 6-15 of gestation then killed on 19 and foetuses were examined for morphological as well as visceral and skeletal malformations. Results indicated that exposure of female rats to the fungicide TMF induced reduction of fertility, ovarian quiescence, adverse changes in serum biochemistry compared to control group. At the sametime, this fungicide induced pronounced pathological changes in ovaries, uteruses and thryroid glands together with different types of numerical and structural chromosomal aberrations in bone marow cells of exposed animals. All the aforementioned change did not return back to normal status UP to one month after cessation of TMF administration. Exposure of pregnant rats to this fungicide Leads to reduction of foetal weights as well as skeletal and visceral malformations. In conclusion, exposure to the fungicidal TMF Induced sever irreversible adverse, biochemical,  pathological  chromosomal and teratogenic changes with consequent impairment of the reproductive function in female rats.

DOI

10.21608/vmjg.1998.377377

Authors

First Name

W.M.

Last Name

AHMED

MiddleName

-

Affiliation

Department of Animal Reproduction and Artificial Insemination, National Research Centre, Cairo, Egypt.

Email

-

City

-

Orcid

-

First Name

H. M.

Last Name

DESOUKY

MiddleName

-

Affiliation

Department of Animal Reproduction and Artificial Insemination, National Research Centre, Cairo, Egypt.

Email

-

City

-

Orcid

-

First Name

H. A. AMER

Last Name

KARIMA

MiddleName

-

Affiliation

Department of Animal Reproduction and Artificial Insemination, National Research Centre, Cairo, Egypt.

Email

-

City

-

Orcid

-

First Name

G.M.

Last Name

MAHMOUD

MiddleName

-

Affiliation

Department of Animal Reproduction and Artificial Insemination, National Research Centre, Cairo, Egypt.

Email

-

City

-

Orcid

-

First Name

Y.F.

Last Name

AHMED

MiddleName

-

Affiliation

Department of Animal Reproduction and Artificial Insemination, National Research Centre, Cairo, Egypt.

Email

-

City

-

Orcid

-

Volume

46

Article Issue

4

Related Issue

49902

Issue Date

1998-10-01

Receive Date

2024-08-31

Publish Date

1998-10-01

Page Start

833

Page End

847

Print ISSN

1110-1423

Online ISSN

2537-1045

Article File

VMJG_Volume 46_Issue 4_Pages 833-847.pdf

PDF . 5.2MB

Link

https://vmjg.journals.ekb.eg/article_377377.html

Detail API

https://vmjg.journals.ekb.eg/service?article_code=377377

Order

377,377

Publication Type

Journal

Publication Title

Veterinary Medical Journal (Giza)

Publication Link

https://vmjg.journals.ekb.eg/

MainTitle

EFFECT OF THE FUNGICIDE (TRI-MILTOX FORT) ON SOME REPRODUCTIVE ASPECTS IN FEMALE RATS

Details

Type

Article

Created At

23 Dec 2024