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377375

EFFECT OF MARSHAL (CARBOSULFAN,METHYL CARBAMATE) ON REPRODUCTIVE SYSTEM AND THYROID GLAND OF MALE RATS

Article

Last updated: 03 Jan 2025

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Subjects

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Tags

Pharmacology
Physiology/endocrinology

Abstract

Oral administration of Marshal (carbosulfan, methyl carbamate) in doses of 4.20 and 10.50mg/kg b.wt. daily for 65 successive days significantly increased the weight of testes and decreased the weight of prostates and epididymes. Epididymal sperm characters including sperm motility and concentration were reduced, while the sperm abnormalities were increased. Moreover, the activity of testicular enzymes lactate dehydrogenase (LDH), alkaline Phosphatase (ALP), and gamma-giutamy1 transferase (GGT) were increased, while the activity of acid phosphatase was decreased. Marshal increased the weight of thyroid glands and the Plasma level of thyroid stimulating hormone (TSH), while triiodothyronine (T3) and thyroxine (T4) were reduced. Regarding some biochemical parameters, Marshal decreased the blood Glucose level and reduced the plasma activities of  aspartate amino-transferase (AST) and alanine amino-transferase (ALT), while total cholesterol was increased. Moreover, Marshal induced histopathological alterations in testes and livers. Thus, Marshal has been shown to induce marked structural and functional changes in reproductive system and thyroid glands of male rats.

DOI

10.21608/vmjg.1998.377375

Authors

First Name

G.S.

Last Name

Eassa WY

MiddleName

-

Affiliation

Department of Physiology, Fac. Vet. Med., Cairo University

Email

-

City

-

Orcid

-

First Name

HANAN, M.

Last Name

SOBBHY

MiddleName

-

Affiliation

Dept. of Pharmacology, Animal Health Research institute, Cairo

Email

-

City

-

Orcid

-

Volume

46

Article Issue

4

Related Issue

49902

Issue Date

1998-10-01

Receive Date

2024-08-31

Publish Date

1998-10-01

Page Start

809

Page End

819

Print ISSN

1110-1423

Online ISSN

2537-1045

Article File

VMJG_Volume 46_Issue 4_Pages 809-819.pdf

PDF . 3.5MB

Link

https://vmjg.journals.ekb.eg/article_377375.html

Detail API

https://vmjg.journals.ekb.eg/service?article_code=377375

Order

377,375

Publication Type

Journal

Publication Title

Veterinary Medical Journal (Giza)

Publication Link

https://vmjg.journals.ekb.eg/

MainTitle

EFFECT OF MARSHAL (CARBOSULFAN,METHYL CARBAMATE) ON REPRODUCTIVE SYSTEM AND THYROID GLAND OF MALE RATS

Details

Type

Article

Created At

23 Dec 2024