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377339

EFFECT OF MALACHITE GREEN ON THE EFFICACY AND PHARMACOKINETICS OF OXYTETRACYCLINE WITH SPECIAL REFERANCE TO THEIR BIOCHEMICAL AND HORMONAL CHANGES IN EXPERIMENTALLY INFECTED CLAR

Article

Last updated: 03 Jan 2025

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Subjects

-

Tags

Pharmacology
Physiology/endocrinology

Abstract

The effect of malachite green on the efficacy, pharmacokinetics and tissue depletion of oxytetracycline was studied in Clarias lazera (catfish) experimentally infected with Aeromonas hydrophila . Infected fish were exposed to oxytetracycline (100 mg L-1) as a bath with or without malachite green ( 2 mgL-1) for 15 minutes daily for 7 consecutive days. The obtained results showed that malchite green augmented the efficacy of oxytetracycline by reducing the mortalities and enhanced its elimination from serum and tissue .The elimination half-life was (T1/2el) of 11.748± 0.52 hours and mean residual time(MRT) was of 17.337 + 0.88 hours. Residues of oxytetracycline were detected in muscles UP to 15 days after the cessation of treatment when it was given alone. While malachite green enhanced the residue depletion of oxytetracycline from muscles, as it could not be detected up to 10 days in fish treated with both agents. The combination of oxytetracycline and malachite green increased the gonadal secretion of sex steroids (either testosterone or 17-β estradiol) via elevation of gonadotropin (LH) levels in both sexes. The liver and kidney functions and glucose utilization were also improved in experimentally infected fish treated with both drugs rather than the use of oxytetracycline alone allover the withdrawal periods.

DOI

10.21608/vmjg.1998.377339

Authors

First Name

K.

Last Name

ABO EL-SOOUD

MiddleName

-

Affiliation

Departments of Pharmacology, Faculty Of Veterinary Medicine; Cairo University; Giza 12211. Egypt

Email

-

City

-

Orcid

-

First Name

H.I.

Last Name

ABASS

MiddleName

-

Affiliation

Departments of Physiology Faculty Of Veterinary Medicine; Cairo University; Giza 12211. Egypt

Email

-

City

-

Orcid

-

Volume

46

Article Issue

4

Related Issue

49902

Issue Date

1998-10-01

Receive Date

2024-08-30

Publish Date

1998-10-01

Page Start

555

Page End

567

Print ISSN

1110-1423

Online ISSN

2537-1045

Article File

VMJG_Volume 46_Issue 4_Pages 555-567.pdf

PDF . 4.8MB

Link

https://vmjg.journals.ekb.eg/article_377339.html

Detail API

https://vmjg.journals.ekb.eg/service?article_code=377339

Order

377,339

Publication Type

Journal

Publication Title

Veterinary Medical Journal (Giza)

Publication Link

https://vmjg.journals.ekb.eg/

MainTitle

EFFECT OF MALACHITE GREEN ON THE EFFICACY AND PHARMACOKINETICS OF OXYTETRACYCLINE WITH SPECIAL REFERANCE TO THEIR BIOCHEMICAL AND HORMONAL CHANGES IN EXPERIMENTALLY INFECTED CLAR

Details

Type

Article

Created At

23 Dec 2024