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377336

THE THERAPEUTIC EFFICACY OF DORAMECTIN , IVERMECTIN AND LEVAMISOLE AGAINST DIFFERENT STAGES OF TRICHINELLA SPIRALIS INFECTION IN RATS

Article

Last updated: 03 Jan 2025

OverviewSimilar Items

Subjects

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Tags

Parasitology and parasitic diseases
Pharmacology

Abstract

In this study, 3 commonly used anthelmintics are tried in experimental Trichinella spiralis infection in an attempt to reach a successful treatment. Doramectin (0.2 mg/kg), ivermectin (0.2 mg/kg) and levamisole (7.5 mg/kg) were tested for their anthelmintic efficacies against experimental T. spiralis infection in rats. Animals were infected with 500 larvae and the drugs were tested against adult worms at 4th day, migrating larvae at 10th day and encysted larvae at 35th day post-infection. Rats were sacrificed, 5 days post treatment. Mature worms and migrating larvae counts were significantly reduced in doramectin and ivermectin medicated rats compared with non-treated controls. Levamisole was the least effective drug with 4.83 and 3.57 % efficacies against mature worms and migrating larvae, respectively. Doramectin showed the highest efficacy in eliminating both mature worms and migrating larvae of T. spiralis (97.75 and 86.23 % , respectively ) followed by ivermectin ( 94.99 and 83.85 %, respectively). The tested anus failed to attack the encysted larvae in the diaphragms of infected rats. Moreover, experimental infection of rats with spiralis, significantly reduced the values of total proteins and albumin while globulin, urea and creatinine values and the activities of AST and ALT were significantly increased. Doramectin and ivermectin induced an improvement in the previous parameters when given at 4th and 10th days post-infection but failed when injected at 35th day post-infection.

DOI

10.21608/vmjg.1998.377336

Authors

First Name

GA.

Last Name

Soliman

MiddleName

-

Affiliation

Pharmacology Departments, Faculty of Veterinary Medicine, Cairo university

Email

-

City

-

Orcid

-

First Name

N.M.

Last Name

El-Bahy

MiddleName

-

Affiliation

Parasitology Departments, Faculty of Veterinary Medicine, Tante university

Email

-

City

-

Orcid

-

Volume

46

Article Issue

4

Related Issue

49902

Issue Date

1998-10-01

Receive Date

2024-08-30

Publish Date

1998-10-01

Page Start

527

Page End

541

Print ISSN

1110-1423

Online ISSN

2537-1045

Article File

VMJG_Volume 46_Issue 4_Pages 527-541.pdf

PDF . 4.3MB

Link

https://vmjg.journals.ekb.eg/article_377336.html

Detail API

https://vmjg.journals.ekb.eg/service?article_code=377336

Order

377,336

Publication Type

Journal

Publication Title

Veterinary Medical Journal (Giza)

Publication Link

https://vmjg.journals.ekb.eg/

MainTitle

THE THERAPEUTIC EFFICACY OF DORAMECTIN , IVERMECTIN AND LEVAMISOLE AGAINST DIFFERENT STAGES OF TRICHINELLA SPIRALIS INFECTION IN RATS

Details

Type

Article

Created At

23 Dec 2024