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369218

EFFECT OF CLOSANTEL ON SOME BLOOD PARAMETERS, HISTOPATHOLOGICAL CHANGES AND FETAL DEVELOPMENT IN PREGNANT FEMALE RABBITS

Article

Last updated: 03 Jan 2025

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Subjects

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Tags

Theriogenology / reproductive technology

Abstract

The effect of closantel on some blood parameters, histopathological changes and fetal development was studied on 3 groups of 10 pregnant rabbits cach. The first group was used as a control whereas, the other groups were injected subcutaneously with closantel in a dose of 10 mg/kg body weight twice with one week apart at days 0 (day of mating) and 7of pregnancy (group A) and days 6 and 13 of pregnancy (group B). The results revealed increased y-globulin concentration in the 20th and 28th day of pregnancy in both groups. Esinophil and monocyte numbers were significantly increased in the 20th and 28th day of pregnancy in group A and in the 28th of pregnancy in group B. There was no significant effect of the treatment on total leukocytic count, numbers of lymphocytes, neutrophils, basophiles and red Blood cells. Hemoglobin concentration, packed cell volume (PCV), total protein, albumin, and globulin in the blood (a and B) were within nor- mal levels. Histopathological examination demonstrated activation in the mesenteric lymph nods, spleenic corpuscles and thymus gland in treated animals at both periods. Atretic oocytes in primary follicles in the ovary of the treated rabbits at day 0 and 7 of pregnancy and necrotic changes in hepatic parenchyma and urinefrous tubules were clearer in rabbits treated at days 6 and 13 of pregnancy. The anthelmentic closantel did not cause embryonic or teratogenic effects in rabbits. It Is concluded that closantel has immune stimulatory effects which may contribute to the death of the parasite. It decreased the ovulation rate so it

DOI

10.21608/vmjg.2002.369218

Authors

First Name

MONA

Last Name

ALA-EL-DEEN

MiddleName

-

Affiliation

Biology of Reproduction Department

Email

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City

-

Orcid

-

First Name

SAMIRA

Last Name

EMARA

MiddleName

-

Affiliation

Biology of Reproduction Department

Email

-

City

-

Orcid

-

First Name

S

Last Name

SELIM

MiddleName

-

Affiliation

Pathology Department Animal Reproduction Research Institute, 5 Hadayk El-Ahram Street, P.O. Box 12556, Giza, Egypt

Email

-

City

-

Orcid

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Volume

50

Article Issue

1

Related Issue

49346

Issue Date

2002-01-01

Receive Date

2024-07-25

Publish Date

2002-01-01

Page Start

117

Page End

131

Print ISSN

1110-1423

Online ISSN

2537-1045

Article File

VMJG_Volume 50_Issue 1_Pages 117-131.pdf

PDF . 5.7MB

Link

https://vmjg.journals.ekb.eg/article_369218.html

Detail API

https://vmjg.journals.ekb.eg/service?article_code=369218

Order

369,218

Type

Original Article

Type Code

544

Publication Type

Journal

Publication Title

Veterinary Medical Journal (Giza)

Publication Link

https://vmjg.journals.ekb.eg/

MainTitle

EFFECT OF CLOSANTEL ON SOME BLOOD PARAMETERS, HISTOPATHOLOGICAL CHANGES AND FETAL DEVELOPMENT IN PREGNANT FEMALE RABBITS

Details

Type

Article

Created At

23 Dec 2024