A total of 40 Egyptian foals were examined for isolation of mycoplasma species and bacteria from conjunctiva, nose, nasopharyngeal area, vaginal and rectum. Two mycoplasma strains M. equigenitalium were recovered from all examined sites except the rectum in different, percentages, while M. pulmonis was found only in the nose and nasopharyngeal area. Bacteria obtained from the nasopharyngeal area were related to.5 genera: Staphylococcus, Corynebacterium, Micrococcus, Bacillus, and Eschtrechia. The most predominant Species was S. epidermidis. The presence of mycoplasmas and bacteria in examined cases indicates the possibility of development of infection among the tested animals.