A total of 105 chicken broiler (antibiotic free) with average weight of 1 kg of each were divided into 3 groups (each of 35 broiler). The examined design was carried out as follow, Group (1) was injected (IV) with 5 mg/kg ciprofloxacin daily for 5 successive days, Group (2) was injected (IV) with 2 mg/kg marbofloxacvin daily for 5 successive days and Group (3) was kept as control without injection any type of antibiotics. After the end of the injection at the 5th day, five chicken of each of the 3 groups were slaughtered after day 1st day, 2nd day, 3rd day, 4th day, 5th day, 6th day, 7th day past last injection.
The breast and thigh muscle samples. were screened by ELISA for detection of the residues of ciprofloxacin and marbofloxacin (ppb i.e. µg/kg) as well as examined by sensory test for odour and taste compared with control group. The results revealed that the residues of ciprofloxacin at 1st and 7thday in both breast and thigh muscle were 849 ±1.7 and 885.6±1.81 and 6.0 ± 0.71 and 10.0 ±1.22, respectively. It was noticed that the marbofloxacin residues were recorded till the 4th day only and not detected after that. The statistical analysis using t-student test revealed that three were significant increase in ciprofloxacin residues in thigh muscle more than breast muscle in all days. The recommendations for slaughter chickens post ciprofloxacin and marbofloxacin were reported and the results were discussed.