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355021

Effect of Trace Elements Vanadium and Nikel on Experimentally Diabetic Rats

Article

Last updated: 23 Dec 2024

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Subjects

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Tags

Biochemistry

Abstract

The purpose of this study to investigate the protective and therapeutic effect of vanadylsulphate (Voso4) and nickel chloride (Nicl2) against hyperglycemia and oxidative stress induced by STZ in albino rats. Vanadylsulphate was administrated in a dose 0.5 mg/ml and 1.0 ml in drinking water before and after the induction of hyperglycemia, Nickel chloride was administrated similarly a dose 100μg/ kg body weight by stomach tube. The gained results revealed a significant increase in plasma glucose, total cholesterol, triacylglycerol, LDL-cholesterol, urea and creatinine, and a significant decrease in insulin and HDL-cholesterol, GSH concentration and SOD activity, while ALT& AST ,GSH px activities and MDA concentration, were non significantly affected by STZ injection in rats. Administration of vanadylsulphate and nickel chloride may improve some of the adverse effects induced by STZ in rats. Vanadylsulphate is more effective in lowering blood glucose level than nickel chloride, more over administration of nickel chloride for long time led to increase in urea and creatinine concentration.

DOI

10.21608/vmjg.2017.355021

Keywords

hyperglycemia, vanadylsulphate, Nickel chloride, streptozotocin

Authors

First Name

E

Last Name

Awad

MiddleName

-

Affiliation

Department of Biochemistry and Chemistry of Nutrition, Faculty of Veterinary medicine, Cairo University,

Email

-

City

-

Orcid

-

First Name

N

Last Name

Karim

MiddleName

-

Affiliation

Department of Biochemistry and Chemistry of Nutrition, Faculty of Veterinary medicine, Cairo University

Email

-

City

-

Orcid

-

First Name

S

Last Name

Moussa

MiddleName

-

Affiliation

Department of Biochemistry and Chemistry of Nutrition, Faculty of Veterinary medicine, Cairo University

Email

-

City

-

Orcid

-

Volume

63

Article Issue

1

Related Issue

47592

Issue Date

2017-01-01

Receive Date

2024-05-18

Publish Date

2017-01-01

Page Start

145

Page End

151

Print ISSN

1110-1423

Online ISSN

2537-1045

Article File

VMJG_Volume 63_Issue 1_Pages 145-151.pdf

PDF . 5.0MB

Link

https://vmjg.journals.ekb.eg/article_355021.html

Detail API

https://vmjg.journals.ekb.eg/service?article_code=355021

Order

355,021

Type

Original Article

Type Code

544

Publication Type

Journal

Publication Title

Veterinary Medical Journal (Giza)

Publication Link

https://vmjg.journals.ekb.eg/

MainTitle

Effect of Trace Elements Vanadium and Nikel on Experimentally Diabetic Rats

Details

Type

Article

Created At

23 Dec 2024