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354961

Potential Protective Effect of Vitamin E Against Reproductive Toxicity Induced by Cypermethrin in Male Rats

Article

Last updated: 03 Jan 2025

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-

Tags

Pharmacology

Abstract

This study was performed to examine the possible protective role of vitamin E against insecticide Cypermethrin (CYM) in male rats. Twenty five sexually mature male rats were randomized into 5 groups: group one was kept as a negative control. In the remaining 4 groups, CYM was orally administered at groups of 15 and 7.5 mg kg (corresponding to 1/10 and 1/20 of LD50) alone and / or in combination with vitamin E for 65 successive days. Blood samples were withdrawn for estimation of testosterone, FSH and LH in the serum. Semen analysis, sex organs weights, antioxidant enzymes superoxide dismutase (SOD); glutathione eroxidase (GPx) and catalase, (CAT) enzyme activities in testicular tissue and histopathological changes in testes were the parameters used in this study. The results showed that concurrent administration of vitamin E with CYM improved the relative weight of testes and increased sperm cell concentration and percentages of sperm motility and viability. There were also significant increases in serum testosterone, FSH and LH levels and in antioxidant enzymes activity in testes. This was associated with amelioration of testicular degenerative changes.ln conclusion vitamin E exerts a protective role against testicular toxicity induced by CYM in male rats.

DOI

10.21608/vmjg.2017.354961

Keywords

cypermethrin, Vitamin E, male fertility, Sperms, testosterone

Authors

First Name

Hossny

Last Name

Elbanna

MiddleName

-

Affiliation

Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University

Email

-

City

-

Orcid

-

First Name

M

Last Name

Shalaby

MiddleName

-

Affiliation

Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University

Email

-

City

-

Orcid

-

First Name

Gehan

Last Name

Kamel

MiddleName

-

Affiliation

Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University

Email

-

City

-

Orcid

-

First Name

Ahmed

Last Name

Galal

MiddleName

-

Affiliation

Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University

Email

-

City

-

Orcid

-

First Name

Shimaa

Last Name

Emam

MiddleName

-

Affiliation

Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University

Email

-

City

-

Orcid

-

First Name

Marwa

Last Name

Khattab

MiddleName

-

Affiliation

Department of Pathology, Faculty of Veterinary Medicine, Cairo University

Email

-

City

-

Orcid

-

First Name

Azza

Last Name

Zakaria

MiddleName

-

Affiliation

Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University

Email

-

City

-

Orcid

-

Volume

63

Article Issue

1

Related Issue

47592

Issue Date

2017-01-01

Receive Date

2024-05-17

Publish Date

2017-01-01

Page Start

83

Page End

88

Print ISSN

1110-1423

Online ISSN

2537-1045

Article File

VMJG_Volume 63_Issue 1_Pages 83-88.pdf

PDF . 4.1MB

Link

https://vmjg.journals.ekb.eg/article_354961.html

Detail API

https://vmjg.journals.ekb.eg/service?article_code=354961

Order

354,961

Type

Original Article

Type Code

544

Publication Type

Journal

Publication Title

Veterinary Medical Journal (Giza)

Publication Link

https://vmjg.journals.ekb.eg/

MainTitle

Potential Protective Effect of Vitamin E Against Reproductive Toxicity Induced by Cypermethrin in Male Rats

Details

Type

Article

Created At

23 Dec 2024