This study represents a field trial to increase production of wheat grown under arid conditions.To fulfill this purpose, the experiment was conducted for two successive winter seasons comprising the treatments: biogas manure to satisfy 100% of P and K-requirements (organic P and K, T1), “rock phosphate+feldspar" to fulfill 100% of P and K+ biofertilizers (Bacillus megatherium and Bacillus circulans, T2), 50% organic P and K+ the other 50% as rock phosphate and feldspars+ bioagents (T3), 100% organic-P and K+ biofertiliozers (T4), rock phosphate and feldspars to satisfy 100% of P and K-needs+ bioagents in presence of either potassium humate (T5), humic acid (T6) or fulvic acid (T7), 50% of P and K as biogas manure + 50% of P and K as mineral fertilizers+ bioagents (T8) beside of the reference treatment ( 100% mineral P and K fertilizers) (T9). Results indicated that the treatment T8 recorded the highest increases in wheat growth parameters, grain yield and net revenues. These values exceeded even the corresponding ones of the reference treatment. Moreover, T8 recorded the highest increases in NPK available contents in soil and consequently their contents within grains. Significant-positive correlations were detected between NPK contents in grains and the yield. Additionally, T8 upraised soil organic matter content and, therefore, decreased soil bulk density. In contrast, bio-fertilizers (solely or with organic additives) did not affect wheat growth and productivity. In conclusion, the treatment T8 is guaranteed to increase wheat productivity in arid soils.