Nowadays there was an attitude from fungi were positive in extra and intracellular production of nanoparticles ( NPs) with different in their ability. In order, synthesis of silver, zinc and titanium nanoparticles by pathogenic fungi were became commercially practical and low-cost revival methods for separation of the particles from the fungal mat that can be used routinely in manufacturing procedures. Numerous mechanisms for the synthesis of NPs were reported. Many theories about nanoparticles antimicrobial mechanisms and nanotoxicity on plant ecosystem were proposed. Nanoparticles were considered a good alternative to control phytopathogenic fungi in agriculture. Different shapes and sizes have shown outstanding antifungal activities. Moreover, use of NPs in plant disease control as a novel and fancy approach that may prove effective in the future with the progress of application aspects of nanotechnology has been discussed in detail. Toxicity and safety of nanomaterials in plants and mammalian, future researches which needed also were discussed.