study aimed to apply some parametric and non-parametric statistical methods to analyze productive and economic loss due to diseases in dairy farms, From the summer of 2017 to the winter of 2020, a field survey was carried out in different areas of Egypt, covering (Menofia, Kaliobia, El Behira, and El Giza) province, on random sampling of dairy producing sectors. Farmers, the private sector, and the governmental were amongst these sectors. This study investigated several dairy breeds: Balady (a native breed), Holstein-Friesian (an alien breed), and Cross-bred (Balady X Friesian). The results concluded that, the statistical tests (Analysis of variance test, t-test, and Chi²-test were effective tools to evaluate the diseases losses in dairy animals especially cattle and buffaloes . The higher incidence of productive and reproductive disorders in buffaloes was reported in anestrous (33.5%), inactive ovaries (31.2%), silent heat (22.6%), endometritis (13.2%) and clinical mastitis (11.7%). Where, the lower incidence was repeated breeder (8.8%), retained placenta (7.5%), lameness (4.3%), and abortion (1.8%) respectively. While, in cattle, the incidence of productive and reproductive disorders reported was from highest to lowest as follows clinical mastitis (29%), endometritis (25.5%), lameness (17.4%), repeat breeder (14.2%), retained placenta (13.3%), anestrous (7%), inactive ovaries (5.7%), silent heat (5.1%) and abortion (1.2%) respectively.