Diabetes is a chronic metabolic, which contributes to disease progression and complications. Baobab is a tropical fruit tree known for its medicinal properties and rich content of antioxidants and anti-inflammatory compounds. This research aimed to investigate the potential anti-inflammatory effects of baobab (Adansonia digitata) in an induced diabetic rat. The study utilized an interventional design and divided the rats into various treatment groups, including a control group, diabetic group, and groups treated with baobab extract, metformin, or a combination of both. Blood samples were collected at various time points to evaluate blood sugar levels, tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and interleukin-10 (IL-10) levels. The results showed that baobab and metformin, either alone or in combination, significantly reduced blood sugar levels compared to the positive control group. Additionally, baobab demonstrated a potential for reducing TNF-α, IL-6, and IL-10 levels, indicating its anti-inflammatory effects in the diabetic model. These findings suggest that baobab may have therapeutic implications in managing inflammation associated with diabetes. However, further research is required to fully elucidate the underlying mechanisms and evaluate the clinical effectiveness of baobab in human subject.