Introduction: Professionalism means the collection of values and skills that distinguish the attitude of humanism in professional work. Inter-professional collaboration, lifelong learning and empathy are components of medical professionalism that have been associated with professional well-being in health care staffs. Aim of Work: - To assess the overall perception of well-being and the general state of health of a sample of health professionals ending their internship year, to evaluate empathic attitude in dealing with patients, inter-professional collaborative work skills, and lifelong learning skills and to recognize which of these three elements have a positive influence on the overarching wellbeing of the sample of health professionals. Materials and Methods: The Scale of Life Satisfaction (SWLS) and the General Health Questionnaire (GHQ-28) were used, respectively, to assess the impression of wellbeing and overall general healthstate. Teamwork was assessed by The Jefferson Scale of Attitudes toward Physician- Nurse Collaboration (JSAPNC), lifelong learning assessed by The Jefferson Scale of Physicians Lifelong Learning (JeffSPLL), and Jefferson's scales of empathy were used to gauge professionalism (JSE-HP). To explain the linear link between the overall feeling of well-being and the other factors under study, a multiple regression model was created. Results: The study was conducted on 226 students half of them were medical students and others were nursing students, 116 (51.3 %) were males. The mean age of studied group was 23.9±1.7 years. There was a significant difference between medical and nursing students regarding SWLS, the mean score was 31.3 (3) and 18.5 (6.1) among medical and nursing students respectively. Multiple regression revealed that sex, discipline, anxiety and insomnia (GHQ), JSE and JSAPNC were associated with global wellbeing. Conclusion: The findings of the current study demonstrated the critical role which professionalism plays in enhancing the general wellbeing ofhealthcare practitioners