Field 
trials were conducted to evaluate the biological activity of quinoa extracts using different parts and solvents against the cotton leafworm Spodoptera littoralis under laboratory conditions. The results concluded that saponin extract, water and acetone extracts of quinoa grains, followed by water, acetone and ethanol extracts of quinoa leaves and roots were very active against cotton leafworm especially after four days of exposure periods with 100% corrected mortalities percentage. Ethanol extract of quinoa grains and hexane extract of quinoa leaves as well as roots showed 90% corrected mortalities against cotton leafworm after four days of exposure periods. However, all stem extracts and leaf extracts using hexane and petroleum ether showed the least toxicity against the cotton leafworm with corrected mortalities between 54.0 to 20.0%. While ether extract of quinoa roots and grains showed 80.0 and 75.0% corrected mortalities, respectively after four days of treatment and calculated lethal concentration (LC₅₀) values were in opposite relationship with the time post-treatment for all the tested treatments, after 1, 2, 3 and 4 days of treatment. The results of concentrations using efficiency (CUE) showed that the highest efficiency rate was recorded when using saponin, grains, leaves and roots extracted from quinoa plants at a concentration of 20, 40%. The results suggest that all extractions are associated with the death of cotton leafworms and have potential insecticidal activity. Further investigations may be needed to develop formulation from quinoa extracts to include in Spodoptera littoralis integrated management programs.