The present experiment was conducted to investigate the effects of five different lipid levels (6,8,10, 12 and 14%) under two different levels of salinity (15 and 30ppt) on growth performance, feed utilization, survival, and economic evaluation of the white leg shrimp Litopenaeus vannamei post-larvae. The experiment was carried out in 20 rectangular tanks (66x47x44cm, 50L), with water salinity of 15 and 30ppt over a period of 90 days. Each treatment had 3 replicates; each tank contained 30 post-larvae with an initial body weight of 0.02± 0.001g. The shrimp samples were fed with the experimental diets containing 35% crude protein twice daily till satiation. Moreover, the growth performance of shrimp was recorded biweekly. The best treatment, which contained 6% lipid and salinity of 30ppt, showed the best results in terms of growth performance, feed utilization, survival (%), and economic evaluation under these experimental condition.