The main objective of this study was to investigate the effect of supplement enzyme mixture for local ewes and rams on nutrients digestibility coefficients, rumen fluid parameter, milk production, some blood plasma parameters and lambs performance. Twenty-one of pregnant ewes at the last sixty days of pregnancy were divided into three groups (seven ewes each), according to their average live body weight. the treatment groups were control or basal diet without enzyme additives, the second (T1) and third (T2) groups animals received basal diet with 30 and 60 g enzyme mixture /100 kg concentrate feed mixture (CFM) , respectively. The experimental period lasted for three months after lambing. Results showed that the enzyme mixtures supplementation to ewes diets did not affect on nutrient digestibility and nutritive values of exponential diets. The average milk yield during lactation period was higher (P<0.05) in T1 than other groups. However, no significant differences were detected between T1 and T2, or between T2 and control groups. Milk fat was increased (P< 0.05) with supplement the low level of enzyme mixtures as compared with the highest one. Ruminal total volatile fatty acids (TVFA's) were higher in T1 than other groups. Also, the concentration of ammonia nitrogen (NH3-N) was higher (P<0.05) for treated groups than control one. The total protein and globulin were increased (P<0.05) in (T1) when compared with T2 and control groups. Average daily gain in