A pot experiment was conducted during season 2020/2021 to study the effect of compost application and microbial inoculants on growth and p-content of faba bean (Vicia faba) c.v. Giza-834 plants grown on sandy calcareous soil. The experimental treatments were arranged as split plots with 8 replications. The main plots were devoted to compost application at a rate 5 t/fad. (Without compost and with compost), whereas the subplots were assigned for microbial inoculants: 1, uninoculated; 2, inoculated with Bacillus polymexia; 3, inoculated with yeast strain Saccharomyces cervisiae; 4, inoculated with Bacillus polymexia + yeast strain Saccharomyces cervisiae. Faba bean Seeds of all treatment were inoculated with Rhizobium leguminosarum. The obtained results of shoots and roots, fresh and dry weights, N and P content in shoots, as well as nodules numbers were significantly increased by compost application compared with control (without compost). The microbial inoculation treatments (rhizobia + either Yeast or Bacillus), were also significantly affected (the shoots and roots, fresh and dry weights, N and P content in shoots, as well as nodules numbers). Also, Signification positive interactions were recorded between compost application and the microbial seed inoculation treatment (R + Yeast) on nodules number and their dry weights, root and shoot fresh and dry weights, N and P content in shoot, seed yield and N and P content in seed and straw.