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352618

Potential Protective Effects of Ethanolic Extract of Butterfly Pea (Clitoria ternatea Linn) Flower Against Carbon Tetrachloride-Induced Hepatotoxicity Rats

Article

Last updated: 01 Jan 2025

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Subjects

-

Tags

Food Science and technology

Abstract

The current study was carried out to explore the hepatoprotective properties of ethanol-derived Clitoria ternatea flower extract (CTEE) on liver injury induced by carbon tetrachloride in rats. It was observed that rats injected with carbon tetrachloride (CCl4) exhibited significant (p≤0.05) reductions in various biological parameters like BWA, FI, and FER, with percentages of -42.86%, -36.99%, and -30.14%, respectively, compared to rats in the control group. Moreover, in comparison to the rats in the normal group, biochemical parameters like total bilirubin (TB), AST, ALT, ALP, and 129.90 liver enzyme activities showed significant (p≤0.05) elevations at 77.28, 129.90, 158.72, and 412.84%, respectively. Along with a decrease in the level of non-enzymatic antioxidants (GSH and GSSG) and an increase in the level of oxidants (MDA and NO2), this was also correlated with an imbalance in certain antioxidant parameters and oxidants in the blood. Each of these parameters suggested that CCl4 was the cause of the liver injury. Rat protocol feeding with CTEE intervention produced a significant (p≤0.05) improvements in all previous biological, biochemical, and oxidant/antioxidant status markers, indicating protection against hepatotoxicity. Furthermore, a dose-dependent pattern was seen in the rate of improvement for each of these parameters. In conclusion, CTEE demonstrated efficacy in preventing liver disorders caused by CCl4. It is therefore advised that we include such plant parts (flowers of Clitoria ternatea) in our daily diets, beverages, and pharmaceutical formulae at concentrations of up to 400 mg/kg bw/day.
 

DOI

10.21608/asejaiqjsae.2024.352618

Keywords

Clitoria ternatea, body weight, Liver functions, glutathione fractions, malonaldehyde, nitrite

Authors

First Name

Neveen

Last Name

A. El-wardany

MiddleName

-

Affiliation

Home Economics Department, Faculty of Specific Education, Alexandria Univ., Alexandria, Egypt

Email

nevenmr@gmail.com

City

-

Orcid

-

First Name

Mariam

Last Name

Abdel-Kader

MiddleName

Ahmed

Affiliation

Alexandria University ,Faculty of Specific Education Home Economy Department

Email

amrym4025@gmail.com

City

الاسكندرية

Orcid

-

Volume

45

Article Issue

1

Related Issue

45054

Issue Date

2024-03-01

Receive Date

2024-02-25

Publish Date

2024-03-31

Page Start

203

Page End

217

Print ISSN

1110-0176

Online ISSN

2536-9784

Article File

ASEJAIQJSAE_Volume 45_Issue 1_Pages 203-217.pdf

PDF . 1.1MB

Link

https://asejaiqjsae.journals.ekb.eg/article_352618.html

Detail API

https://asejaiqjsae.journals.ekb.eg/service?article_code=352618

Order

17

Type

Original Article

Type Code

53

Publication Type

Journal

Publication Title

Alexandria Science Exchange Journal

Publication Link

https://asejaiqjsae.journals.ekb.eg/

MainTitle

Potential Protective Effects of Ethanolic Extract of Butterfly Pea (Clitoria ternatea Linn) Flower Against Carbon Tetrachloride-Induced Hepatotoxicity Rats

Details

Type

Article

Created At

23 Dec 2024